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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PXN All Species: 28.18
Human Site: S536 Identified Species: 51.67
UniProt: P49023 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49023 NP_001074324.1 591 64533 S536 E R R G S L C S G C Q K P I T
Chimpanzee Pan troglodytes XP_001159942 589 64154 S534 E R R G S L C S G C Q K P I T
Rhesus Macaque Macaca mulatta XP_001085795 563 61555 S508 E R R G S L C S G C Q K P I T
Dog Lupus familis XP_543425 664 72715 S609 E R R G S L C S G C Q K P I T
Cat Felis silvestris
Mouse Mus musculus Q8VI36 591 64458 S536 E R R G S L C S G C Q K P I T
Rat Rattus norvegicus Q66H76 586 64001 S531 E R R G S L C S G C Q K P I T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P49024 559 61224 S504 E R R G S L C S G C Q K P I T
Frog Xenopus laevis Q2TCH4 506 55983 T463 P I T G R C V T A M G K K F H
Zebra Danio Brachydanio rerio Q6P7E4 419 45574 L376 I D A G D R F L E A L G Y S W
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_523601 581 64668 A526 A K R G S L C A G C S K P I T
Honey Bee Apis mellifera XP_624308 559 62451 A504 A K R G S L C A G C H K P I T
Nematode Worm Caenorhab. elegans Q09476 413 46434 R370 R C V A A M G R K F H P E H F
Sea Urchin Strong. purpuratus XP_780574 695 76058 A640 A V R G S L C A G C N K P I T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 92.5 83.1 N.A. 93.7 74.9 N.A. N.A. 84.7 41.2 21.6 N.A. 43.1 43.3 33.8 43.4
Protein Similarity: 100 99.1 92.8 85.2 N.A. 95.7 78.3 N.A. N.A. 88.4 54.3 36.5 N.A. 54.8 57 47 56.2
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 13.3 6.6 N.A. 73.3 73.3 0 73.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 20 6.6 N.A. 86.6 86.6 13.3 80
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 24 0 8 8 8 0 0 24 8 8 0 0 0 0 0 % A
% Cys: 0 8 0 0 0 8 77 0 0 77 0 0 0 0 0 % C
% Asp: 0 8 0 0 8 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 54 0 0 0 0 0 0 0 8 0 0 0 8 0 0 % E
% Phe: 0 0 0 0 0 0 8 0 0 8 0 0 0 8 8 % F
% Gly: 0 0 0 93 0 0 8 0 77 0 8 8 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 16 0 0 8 8 % H
% Ile: 8 8 0 0 0 0 0 0 0 0 0 0 0 77 0 % I
% Lys: 0 16 0 0 0 0 0 0 8 0 0 85 8 0 0 % K
% Leu: 0 0 0 0 0 77 0 8 0 0 8 0 0 0 0 % L
% Met: 0 0 0 0 0 8 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % N
% Pro: 8 0 0 0 0 0 0 0 0 0 0 8 77 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 54 0 0 0 0 % Q
% Arg: 8 54 77 0 8 8 0 8 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 77 0 0 54 0 0 8 0 0 8 0 % S
% Thr: 0 0 8 0 0 0 0 8 0 0 0 0 0 0 77 % T
% Val: 0 8 8 0 0 0 8 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _